It is the trademark name of the medical product, "Sildinaville", and the date of March 27, 1998 is the date of the certification of this type of real estate for human use.
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Viagra
In this brief theme, we will learn about the story of its discovery, which can be said to be funny, and how it was not originally intended to treat erectile dysfunction, and that this feature was discovered by chance.
A drug project for the treatment of blood pressure and angina
Viagra was made in England by a group of pharmaceutical chemists working at Pfizer.
The researchers' study was initially focused on the use of this drug to treat blood pressure and angina, and the first clinical trials were conducted at Morriston Hospital in Swansea, UK, at which time the effectiveness of Viagra was discovered to treat erectile dysfunction by accident.
Animal experiments
The researchers were initially studying to treat cardiovascular problems, where the cardiovascular aneurysm was supposed to prevent a specific protein called "PDE-5" in animal tests. The researchers are evidence that it hinders "PDE-5"and there were no obvious negative side effects on animals.
Experiments and the funny discovery of humans
Sydenville was introduced in clinical trials in humans in the early 1990s, but the bad news was that preliminary results showed that the drug had little effect on angina.
The strange news that turned out to be good news was what the nurses who were supervising the men involved in the study, said John Lamatina, who was head of research and development at Pfizer during this research: The nurses noticed that when examining the men, many of them were They lay on their stomachs and were embarrassed because they felt erect.
It turns out that dilated blood vessels were not in the heart but the penis, and because the dilation of blood vessels is an essential part of the process leading to the erection, the result was amazing, so Pfizer decided to market this drug to treat erectile dysfunction and not angina.
The patent was patented in 1996 and approved for use in the treatment of erectile dysfunction by the U.S. Food and Drug Administration on March 27, 1998, becoming the first oral treatment for erectile dysfunction in the United States.
Viagra has become one of the biggest successes in the history of the pharmaceutical industry, for example, its annual sales in 2008 reached $1.934 billion, and since 2012 the United States, Mexico and Canada have spent about $1.4 billion annually.
These figures are expected to decline in the coming years when Pfizer's patent expires on the drug in 2020.
Viagra works by responding to sexual stimulation, increasing blood flow to the penis, leading to erection, but in return it does not increase sexual arousal and does not lead to an erection of the penis without a stimulus.
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